Preparation and evaluation of borneol sustained-released microcapsules modified by Eudragit RS 30D
Objective To study the optimal process for preparing borneol microcapsules with sodium alginate and Eudragit RS 30D(SA/RS 30D/BN MCs),and carry out related characterization.Methods The SA/RS 30D/BN MCs was prepared by complex coacervation method.The effects of mass concentrations of borneol,soluble starch,Tween 80,sodium alginate(SA)solution,Eudragit RS 30D and CaCl2 solution on the quality of microcapsules were investigated by the single factor method with encapsulation rate and drug loading capacity as the assessment indicators.Then,the optimal formulation was screened by L9(34)orthogonal test with the encapsulation rate as the assessment indicator.The appearance,physical and chemical properties,in vitro release behavior,preliminary stability of the optimal formulation was evaluated.Results The optimal of SA/RS 30D/BN MCs was as follows:borneol,soluble starch,Tween 80,sodium alginate,Eudragit RS 30D,CaCl2 with mass concentrations of 3.33%,0.17%,0.17%,1.00%,5.00%,1.50%,respectively.The average encapsulation rate was(94.18±0.47)%and the drug loading was(30.42±0.17)%.In the preliminary stability test,the retention rate of borneol in the microcapsules reached 92.2%,and the characterization results showed that borneol microcapsules with sustained release performance were successfully prepared.Conclusion The borneol microcapsules prepared by complex coacervation method with sodium alginate and Eudragit RS 30D as composite capsules can significantly improve the stability of borneol and have a certain sustained release effect.
万方数据
维普
