Analysis of drug resistance of common antibiotics in patients with lower respiratory infection caused by Klebsiella pneumoniae
Objective To analyze the resistance to common antibiotics in patients with lower respiratory infection(LRI)caused by Klebsiella pneumoniae(KPN).Methods A total of 514 patients with LRI caused by KPN in our hospital from October 2022 to September 2023 were selected,sputum samples were collected,and the detection status of KPN,extended spectrum β-lactamases(EBLS)+ strains,EBLS-strains and carbapenem resistant Klebsiella pneumoniae(CRKP)were analyzed.Drug sensitivity tests were performed to analyze the resistance of KPN,EBLS+ strains,EBLS-strains and CRKP strains to commonly used antimicrobial drugs.Results A total of 514 KPN strains were isolated,including 94 EBLS+ strains(18.3%),310 EBLS-strains(60.3%)and 110 CRKP strains(21.4%).KPN was the most sensitive to tigecycline(99.8%).The resistance rate of EBLS+ strain to most commonly used antibiotics was higher than that of EBLS-strain.Except for tigecycline,CRKP strains had a high resistance rate to all commonly used antimicrobials,>80.0%.Conclusion EBLS+ strains,EBLS-strains and CRKP strains are isolated from patients with LRI caused by KPN,and different strains have different rates of resistance to different antimicrobial drugs,which need to be cultured and identified in order to understand the rate of resistance,and to help clinicians rationally select antimicrobial drugs for treatment.
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维普
