The research progress of anti-tumor main active ingredients and mechanism of Pingxiao Capsule
Traditional Chinese medicine Pingxiao Capsule is composed of Yu Jin(Zingiberaceae),Xian He Cao(Rosaceae),Wu Ling Zhi(Feces trogopterus),Bai Fan(Alunite),Xiao Shi(Nitre),Gan Qi(Anacardiaceae),Zhi Ke(Rutaceae),Ma Qian Zi(Loganiaceae).It has the effects on activating blood circulation and removing blood stasis,dispersing knots and swelling,detoxifying and relieving pain,and it is mainly used as adjunctive anti-tumor therapy.So far,89 alkaloids,flavonoids,organic acids and phenolic compounds have been isolated from Pingxiao Capsules,among which the key active ingredients are alkaloids and flavonoids.Modern pharmacology has found that Pingxiao Capsule has inhibitory effects on many malignant tumors,such as thyroid cancer,lung cancer,nasopharyngeal cancer,breast cancer,digestive tract tumors and so on.The main mechanism of its anti-tumor effect includes targeting tumor cells,which is specifically manifested as inhibiting tumor angiogenesis,regulating tumor cell proliferation,apoptosis and metastasis,etc.It also includes acting on bone marrow and immune cells to improve the level of immunity,and synergizing with other anticancer drugs to increase sensitivity,enhance efficacy and reduce the toxicity.This article reviews the latest progress of the main active ingredients and mechanism of action of Pingxiao Capsule in anti-tumor therapy,aiming to provide reference for the subsequent in-depth excavation of the effective substances of Pingxiao Capsule in anti-tumor therapy and their greater clinical application value.
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