Analysis of risk factors for pulmonary infection in patients with chronic obstructive pulmonary disease related pulmonary arterial hypertension
Objective To investigate the risk factors for pulmonary infection in patients with chronic obstructive pulmonary disease(COPD)related pulmonary hypertension(PH),and to provide reference for clinical prevention and treatment.Methods The clinical data of 167 patients with COPD related PH admitted to the Second Affiliated Hospital of Guangzhou Medical University from January 2012 to December 2021 were retrospectively analyzed,and they were divided into infected group(85 cases)and uninfected group(82 cases)based on whether there is concurrent pulmonary infection.The clinical characteristics,laboratory test indexes,and risk factors were compared between the two groups.Results Among 167 COPD related PH patients,85 cases were complicated with pulmonary infection,accounting for 50.9%.Univariate analysis showed that smoking history,the New York Heart Association(NYHA)classification(Ⅱ,Ⅲ,Ⅳ),severe disease,hospital length of stay,hospitalization cost,pulmonary artery systolic blood pressure(PASP),brain natriuretic peptide(BNP),C-reactive protein(CRP),and white blood cell count in the infected group were significantly higher than the uninfected group(P<0.05).The body mass index(BMI),serum albumin,total cholesterol and triglyceride of infected group were significantly lower than those of uninfected group(P<0.05).Multivariate Logistic regression analysis showed that smoking history,NYHA grade(Ⅱ,Ⅲ,Ⅳ),severe disease,and elevated BNP were independent risk factors for pulmonary infection in patients with COPD related PH(P<0.05).Conclusion In the clinical treatment process,it is important to actively treat and control the high-risk factors for pulmonary infection in patients with COPD related PH,in order to effectively reduce the probability of pulmonary infection in patients.
万方数据
维普
