Progress on anti-motion sickness drugs and their sustained-release preparations
Motion sickness(MS)is a series of physiological responses such as dizziness and vomiting in human being caused by abnormal movement stimulation.Recently,most of anti-motion sickness drugs mainly include antihistamines,anticholinergic drugs,calcium antagonists,sympathomimetic drugs,and gastric motility drugs,and most of them are common preparations,while the development and application of sustained-release preparations are few.This article reviews the pathogenesis of motion sickness,the classification of therapeutic drugs and sustained-release preparations,including transdermal preparations,nasal preparations and oral preparations.Besides,this article also points out the problems and gives some advice during the current research of anti-motion sickness drugs,which will provide new methods for developing new preparations of anti-motion sickness.
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