摘要
BS69位于10号染色体p12.48,在多种癌症中表达下调,包括乳腺癌、卵巢癌、前列腺癌等,因此被认为是一种潜在的肿瘤抑制因子.其在肿瘤中的作用及调控机制复杂多样,可通过NF-κB信号、JNK信号、RAS/MERK等信号通路以及与miRNA相互作用参与调控肿瘤细胞的生长、增殖、侵袭和迁移.除了作为组蛋白突变体H3.3的特异性阅读器之外,BS69还被发现参与RNA剪接调控、细胞衰老、染色质重塑等.本文主要对BS69的基因结构、生理功能、信号通路作用机制、与肿瘤及各种疾病相关性展开综述.
Abstract
BS69 is located at chromosome 10p12.48,and its expression is downregulated in human cancers,including breast cancer,ovarian cancer,prostate cancer,which thus is considered as a potential tumor suppressor.The role and regulatory mechanism of BS69 in tumors are complex and diverse.It can participate in the regulation of tumor cell growth,proliferation,invasion,and migration through signaling pathways such as NF-κB,JNK,RAS/MERK,and its interaction with miRNA.In addition to serving as a specific''reader''for histone variant H3.3,BS69 has also been found to be involved in RNA splicing regulation,cellular senescence,chromatin remodeling and more.This paper mainly reviews the gene structure,physiological function,signaling pathway mechanism and correlation with tumors and various diseases of BS69.
基金项目
广东省基础与应用基础研究基金(2022A1515140084)
维普
万方数据