The impact of matrix composition on the needle formation and penetration of soluble microneedles containing anti-tumor drug resveratrol
Objective To evaluate how the composition of the microneedle matrix influences the formability and penetration performance of resveratrol-soluble microneedles,so as to improve the transdermal delivery efficiency of resveratrol,an anti-tumor drug.Methods Resveratrol-soluble microneedles(Res-DMNs)were prepared by utilizing a multi-step reduced pressure diffusion method.The formability of single-matrix materials with varying degrees of polyvinyl alcohol(PVA)polymerization(PVA-0488,PVA-0588,PVA-1788)and a mixed PVA and polyvinylpyrrolidone(PVP-K30)system were assessed with the film-forming ability,smoothness,bubble count,and needle density as indexes to establish the optimal mixing ratio.The morphology,dissolution performance,mechanical properties,in vitro puncture performance,and ex vivo skin puncture efficiency of the microneedles were then thoroughly evaluated.Results The microneedles fabricated with a PVA-0588 and PVP-K30 mixed matrix demonstrated a needle density exceeding 90%.The microneedle patch featured needle length of approximately 720 μm and tip spacing of about 800 μm.After insertion into the skin,the microneedles were almost completely dissolved within 10 minutes.By measuring fixed skin tissue,the mean puncture depth of the microneedles was(535.23±87.24)μm,accompanied by a puncture rate of 92.4%.Conclusion The formability and penetration performance of resveratrol-soluble microneedles are paramount for their clinical application.The findings have identified an optimal matrix composition,laying a robust foundation for the therapeutic efficacy of these microneedles.These attributes are essential for the clinical application of microneedles,with the suitable matrix material composition being crucial for their therapeutic effectiveness.
resveratrolanticancer agentsdissolving microneedlestransdermal drug deliverypenetrativity
万方数据
维普
