Incidence of hypertriglyceridemia,hypercholesterolemia,and hyperglycemia and their influencing factors in people living with HIV during ART
Objective To study the incidence and factors associated with hypertriglyceridemia(triglyceride≥2.3 mmol/L),hypercholesterolemia(total cholesterol≥6.2 mmol/L),and hyperglycemia(fasting plasma glucose≥6.10 mmol/L)in people living with HIV/AIDS(PLWHA)during antiretroviral therapy(ART).Methods A retrospective cohort study was conducted,which collected baseline and follow-up data from PLWHA who received ART for the first time from 2004 to 2019 in the largest infectious diseases hospital in Guangdong Province.The Cox proportional hazard model was used to explore the factors influencing the incidence of hypertriglyceridemia,hypercholesterolemia,and hyperglycemia in the PLWHA.Results There were 8 839 PLWHA.During ART,hypertriglyceridemia,hypercholesterolemia,and hyperglycemia were present in 4 255(48.14%),1 234(13.96%),and 2 647(29.95%)cases of PLWHA,with a total incidence density of 28.12 per 100 person-years,5.11 per 100 person-years,and 14.22 per 100 person-years,respectively.The results of the Cox proportional hazard model showed that the body mass index(BMI),the year of ART initiation,the baseline WHO clinical stage,the baseline opportunistic infections,the number of clinical symptom categories,initial ART regimen,and the baseline CD4+T cell count were associated with the incidence of hypertriglyceridemia in the PLWHA.The gender,age,the baseline BMI,the year of ART initiation,the baseline WHO clinical stage,the baseline opportunistic infections,the initial ART regimen,and the baseline CD4+T cell count were associated with the incidence of hypercholesterolemia in the PLWHA.The gender,age,the baseline BMI,the year of ART initiation,the route of infection,the baseline opportunistic infections,and the baseline CD4+T cell count were associated with the incidence of hyperglycemia in the PLWHA.Conclusion PLWHA after ART are prone to have hypertriglyceridemia,hypercholesterolemia,and hyperglycemia.It is important to dynamically monitor the levels of blood lipid and blood glucose in PLWHA,especially for patients receiving therapy of lopinavir/ritonavir oral solution(LPV/r).Early intervention should be provided to high-risk patients by adjusting the treatment regimen to prevent the incidence of non-AIDS-defining diseases,such as cardiovascular diseases,and improve the quality of life for patients.
people living with HIV/AIDS(PLWHA)hypertriglyceridemiahypercholesterolemiahyperglycemia
万方数据
维普
