A meta analysis on the effects of cyclosporine dosage and course of treatment on adverse pregnancy outcomes
Objective To systematically evaluate the effects of cyclosporine dose and course of treatment on pregnancy outcomes.Methods The literature of randomized controlled studies and observational studies on the treatment of adverse pregnancy with cyclosporine was searched from the establishment of various scientific databases at home and abroad(CNKI,Wanfang,VIP Medical Network,Pubmed,Cochran Library)to September 2023.Revmen 5.3 was used for quality assessment and meta-analysis of the included studies.Results A total of 19 studies involving 1 902 patients were included,of which 919 patients were treated with cyclosporine.The clinical pregnancy rate,miscarriage rate and adverse reaction rate in the experimental group were 71.2%,12.7%and 4.7%,respectly.In the control group,the clinical pregnancy rate was 55.4%,the miscarriage rate was 25.3%,and the incidence of adverse reactions was 7.1%.The results showed that when the daily dose of cyclosporine was in the range of 240-480 mg,the clinical pregnancy rate of the experimental group was significantly different from that of the control group(P<0.01).The medication course was from 30 days before the start of pregnancy to 12 weeks of pregnancy,and there was a significant difference in the clinical pregnancy rate between the experimental group and the control group(P<0.01).Conclusion At present,limited evidence suggests that cyclosporine can increase the clinical pregnancy rate of adverse pregnancies,reduce miscarriage rates,and have a low incidence of adverse reactions at appropriate doses and reasonable treatment courses.
cyclosporinedrug dosagecourse of treatmentadverse pregnancypregnancy outcomes
万方数据
维普
