Liver disease is one of the main causes of death worldwide and presents a significant public health issue.Target fishing,an innovative drug screening tool,has shown tremendous promise in the screening of active pharmaceutical ingredient because of its high specificity and efficiency.This article reviewed the principles and classifications of targeted fishing technology,as well as its current application status in the prevention and treatment of liver diseases.It summarized the advantages and disadvantages of ligand fishing and target fishing technologies,and explored their future trends.In order to provide patients with liver illness with more effective treatment options and lessen the burden of liver disease worldwide,the existing challenges faced by this technology and potential solutions were also analyzed.
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