Effect of positive lymph node ratio on the prognosis of patients with M0 stage non-small cell lung cancer
Objective To investigate the effect of positive lymph node ratio on the prognosis of M0 stage non-small cell lung cancer.Methods The clinical data of patients with M0 stage non-small cell lung cancer in SEER data-base from 2010 to 2015 were analyzed.The best cut-off point of positive lymph node ratio was selected by X-file software.Univariate and multivariate Cox proportional hazard models were used to explore the prognostic value of positive lymph node ratio in patients with M0 stage non-small cell lung cancer.Kaplan-Meier method was used to draw survival curve to analyze the survival of the two groups.Result The data of 37 001 patients with M0 stage non-small cell lung cancer was extracted from the database.The best cut-off points of positive lymph node ratio selected by X-file were positive lymph node ratio≤0.07 and positive lymph node ratio＞0.07.Age,sex,race,T stage,N stage,Grade stage,time from diagnosis to treatment(month),income,tumor size,lung lobe and systemic treat-ment were independent risk factors affecting overall survival and cancer specific survival of patients with M0 stage non-small cell lung cancer by Cox proportional hazard regression model.Kaplan-Meier survival curve showed that the prognosis of the group with positive lymph node ratio≤0.07 was significantly better than that of the group with positive lymph node ratio＞0.07(P＜0.05).Conclusion The ratio of positive lymph nodes＞0.07 is an independent risk factor for the prognosis of patients with M0 stage non-small cell lung cancer.
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