The application value of dynamic monitoring of ProGRP,NSE,CYFRA21-1,and SCCAg levels in lung cancer chemotherapy
Objective To explore the clinical application value of continuous monitoring of the expression changes of serum ProGRP,NSE,CYFRA21-1,and SCC Ag in different chemotherapy cycles for pathological classification of lung cancer and evaluation of chemotherapy efficacy.Methods 125 confirmed lung cancer patients were selected,including 16 cases of small cell lung cancer(SCLC),32 cases of lung squamous cell carcinoma(LUSC),and 77 ca-ses of lung adenocarcinoma(LUAD).Serum tumor marker levels were continuously measured in patients with dif-ferent cycles of chemotherapy,and their correlation with lung cancer pathological classification,treatment efficacy e-valuation,and prognosis was analyzed.500 healthy examinees were selected as the control group during the same period to establish baseline data for tumor markers in the normal population.Result The levels of ProGRP and NSE in the SCLC group were significantly higher than those in the LUSC and LUAD groups(P＜0.05);The levels of CYFRA21-1 and SCC Ag in the LUSC group were significantly higher than those in the other groups(P＜0.05);The CYFRA21-1 level in the LUAD group was higher than that in the SCLC group(P＜0.05).The levels of Pro-GRP and NSE in the SCLC effective group significantly decreased after chemotherapy(P＜0.05),and were posi-tively correlated with efficacy evaluation(P＜0.05);The levels of CYFRA21-1 and SCC Ag in the LUSC group were significantly lower after chemotherapy than before and during chemotherapy,and were positively correlated with efficacy evaluation(P＜0.05).There was no statistically significant difference in tumor marker levels among patients with PD who received chemotherapy before,during,and after chemotherapy(P＞0.05).There was a sta-tistically significant difference in the levels of CYFRA21-1 and SCC Ag in LUAD patients before and after chemo-therapy(P＜0.05),and CYFRA21-1 and NSE were positively correlated with efficacy evaluation(P＜0.05).Conclusion Continuous dynamic monitoring of ProGRP,NSE,CYFRA21-1,and SCC Ag levels has certain value in the patho-logical classification and chemotherapy efficacy evaluation of lung cancer.
万方数据
维普
