Analysis of correlation and influencing factors between serum PTTG1,VEGF and TK1 levels and short-term prognosis of laryngeal and hypopharyngeal cancer
Objective To explore the correlation between serum PTTG1,VEGF,TK1 levels and the short-term prognosis of laryngeal and hypopharyngeal cancer and the adverse prognostic factors.Methods A total of 117 patients with laryngeal and hypopharyngeal cancer admitted to the affiliated Qingdao central hospital of Qingdao University from January 2017 to December 2021 were selected as the observation group.Another 142 patients with benign laryngeal lesions who were diagnosed during the same period were selected as the control group.Enzyme linked immunosorbent assay was used to detect the serum levels of PTTG1,VEGF,and TK1 in two groups of patients.Patients in the observation group were followed up for a short-term postoperative prognosis of one year,and were divided into a good prognosis group and a poor prognosis group based on the follow-up results.Clinical data and preoperative serum PTTG1,VEGF,TK1 levels were compared between two groups of patients.Spearman correlation analysis was used to investigate the correlation between serum PTTG1,VEGF,TK1 levels and short-term poor prognosis in patients.Univariate and multivariate logistic regression analysis was used to investigate the influencing factors of poor prognosis in patients.Results The serum PTTG1(139.18±25.13)pg/ml,VEGF(466.19±27.14)pg/ml,and TK1(4.09±0.59)pmol/L in the observation group were significantly higher than those in the control group,with statistically significant differences(P＜0.001).Among the 117 patients in the observation group,96 had a good prognosis and 21 had a poor prognosis.There were statistically significant differences in gender,age,tumor diameter,histological differentiation,clinical staging,lymph node metastasis,serum PTTG1,VEGF,and TK1 between the patients with good prognosis and those with poor prognosis(P＜0.05).Spearman correlation analysis showed that serum levels of PTTG1,VEGF,and TK1 were positively correlated with poor short-term prognosis(r=0.593,0.544,0.698,P＜0.01).Logistic analysis showed that age,tumor diameter,histological differentiation,clinical stage,lymph node metastasis,serum PTTG1,serum VEGF,and serum TK1 were all independent influencing factors for poor prognosis(P＜0.05).Conclusions There is a correlation between serum levels of PTTG1,VEGF,and TK1 and the short-term prognosis of laryngeal and hypopharyngeal cancer.There are many factors that affect the short-term prognosis of patients,and they can be comprehensively applied in the prognosis evaluation of diseases.
万方数据
维普
