Value of Glasgow prognostic score and related indexes before radiotherapy in predicting the prognosis of nasopharyngeal carcinoma patients
Objective To study the correlation of Glasgow prognostic score(GPS)and related indexes and the prognosis of nasopharyngeal carcinoma(NPC)patients undergoing radiotherapy.Methods From January 2010 to June 2016,183 NPC patients received radiotherapy in our hospitals were retrospectively collected with patient data and followed up until June 30,2022.Kaplan-Meier method was used to draw the survival curve.Log-rank test and Cox regression were used to analyze the prognostic factors of NPC patients.Results The median follow-up time was 87 months.42 patients died during the follow-up period(23.0％).The 3-year and 5-year overall survival rates of patients were 91.8％and 61.2％,respectively.The analysis of ROC showed that albumin(ALB),lymphocyte count(LYM),body mass index(BMI)and C-reactive protein(CRP)could predict the survival of patients with the optimal cut-off values at 34.85 g/L,1.65× 109/L,22.25 kg/m2 and 8.0 mg/L,respectively(P＜0.05).Univariate analysis showed that tumor stage,T stage,N stage,ALB,LYM,BMI,CRP,NRS 2002 score and GPS were related with the prognosis of NPC patients(P＜0.05).Cox regression analysis showed that GPS(1 point,2 points)and tumor stage(stage Ⅱ and stage Ⅲ)were the risk factors for the prognosis of patients,with HR and 95％CI at 2.473(1.111-5.500:1 point),5.536(1.839-16.652:2 points),1.907(1.218-2.989:stage Ⅱ)and 4.392(1.844-0.468:stage Ⅲ),respectively(P＜0.05).Conclusions The nutritional,inflammatory and immune status before radiotherapy are associated with the clinical prognosis of NPC patients.GPS score and tumor stage can be used as independent predictors of the prognosis of patients.
万方数据
维普
