摘要
孤独症谱系障碍(autism spectrum disorder,ASD)是一种严重的神经发育障碍性疾病,临床以社会交往及语言交流缺陷、刻板行为及兴趣、活动狭窄为主要表现.目前国内外关于ASD发病机制涉及免疫方面的研究不断取得进展.关于细胞因子(如IL-1β、IL-8、IL-17等)及对ASD动物模型的脑组织研究发现,ASD发病与神经系统免疫功能紊乱存在关联,可能继发突触功能损害.该文综述国内外ASD与免疫系统紊乱相关的研究,为探究ASD病因、发病机制及潜在的治疗措施提供思路.
Abstract
Autism spectrum disorder(ASD)is a serious neurodevelopmental disorder,with deficits in social and language communication,rigid behaviors,limited interests and activities.At present,research on the pathogenesis of ASD involving immunity has been making progress worldwide.In terms of cytokines(such as IL-1β,IL-8,IL-17,etc.)and ASD animal models,it has been found that the onset of ASD is associated with nervous system immune dysfunction,which may lead to synaptic function impairment.The purpose of this review is to describe the recent research on ASD and immune dysfunction to provide ideas for exploring the etiology,pathogenesis and potential therapeutic measures of ASD.
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