嗜酸性粒细胞对呼吸道感染性疾病的调节作用
Regulatory role of eosinophils in respiratory infectious diseases
吴朝粉 1陈莉娜1
作者信息
- 1. 四川大学华西第二医院小儿呼吸免疫科 出生缺陷与相关妇儿疾病教育部重点实验室国家卫生健康委员会时间生物学重点实验室(四川大学),成都 610041
- 折叠
摘要
嗜酸性粒细胞是参与寄生虫感染和过敏性疾病发生的重要细胞.近年来研究发现嗜酸性粒细胞参与宿主对细菌、病毒和真菌等感染的免疫反应,通过模式识别受体去识别病原体,利用多种机制发挥免疫防御作用.国内外有关嗜酸性粒细胞在呼吸道感染方面的研究取得了许多进展.该综述对嗜酸性粒细胞对呼吸道感染性疾病的调节作用进行总结,阐述嗜酸性粒细胞活化过程及与呼吸道病原体直接和间接的相互作用,旨在提高临床医生对嗜酸性粒细胞在呼吸道感染性疾病中作用的认识,为临床诊疗提供新思路.
Abstract
Eosinophils are generally considered to play an important role in parasitic infections and allergic diseases.In recent years,eosinophils have also been found to be involved in the host's immune response to infections caused by bacteria,viruses and fungi.Eosinophils recognize these pathogens through pattern recognition receptors,during this process multiple mechanisms are implicated in host's immune defense against infections.Much progress on the role of eosinophils in respiratory tract infections has been reported in recent years.This review summarizes the regulatory role of eosinophils in respiratory infectious diseases,and the activation process of eosinophils and their direct and indirect interaction with respiratory pathogens,hoping to improve the recognition of the role of eosinophils in the pathogenesis of respiratory infectious diseases,and provide new ideas for clinical diagnosis and treatment.
关键词
嗜酸性粒细胞/呼吸道感染/调节作用Key words
Eosinophil/Respiratory tract infection/Regulating effect引用本文复制引用
基金项目
国家自然科学基金(82370001)
四川省重大科技专项(2022ZDZX0021)
中央高校基本科研业务费专项(SCU2022D022)
出版年
2024
NETL
NSTL
万方数据