摘要
气道黏液高分泌是儿童社区获得性肺炎的病理改变之一,影响肺炎严重程度、发展及预后.目前确定气道黏液高分泌依据支气管镜检查所见.为了评估发生气道黏液高分泌的风险,尽早干预,避免发生塑型性支气管炎以及缺氧、呼吸衰竭等严重后果,该文总结了年龄、临床特征及实验室指标与社区获得性肺炎儿童气道黏液高分泌发生率的关系.其中年龄、病原学种类、热峰及热程、中性粒细胞比值、C反应蛋白、乳酸脱氢酶、D-二聚体、血清25-羟基维生素D以及部分白细胞介素家族成员、干扰素及其他获得性免疫指标对社区获得性肺炎儿童气道黏液高分泌的发生具有预警作用.
Abstract
Airway mucus hypersecretion is one of the pathological changes in children with community acquired pneumonia(CAP),and affects the severity,progression and prognosis of CAP.Diagnosis of airway mucus hypersecretion currently relies on fiberoptic bronchoscopy.To predict the risk of airway mucus hypersecretion and to take early action to avoid serious consequences such as plastic bronchitis and hypoxia and respiratory failure,the article summarizes the relationship between age,clinical characteristics and laboratory indices and the formation of airway mucus hypersecretion in children with CAP.Among them,age,pathogenic species,fever peak and fever range,neutrophil ratio,C-reactive protein,lactate dehydrogenase,D-dimer,serum 25(OH)D,and some interleukins,interferons,and acquired immune indicators have an early warning effect on the development of airway mucus hypersecretion in children with CAP.
基金项目
国家重点研发计划(2022YFC2704900)
重庆市自然科学基金(cstc2019jcyjmsxmX0858)
重庆市人力资源和社会保障局留学人员回国创业创新支持计划(cx2019068)
重庆市教育委员会科学技术研究计划(KJQN202000431)
重庆市科卫联合医学科研项目(渝卫发[2020]65号-2020FYYX086)
Chongqing Science and Health Joint Medical Research Project(2020FYYX086)
NETL
NSTL
万方数据