首页|社区获得性肺炎儿童发生气道黏液高分泌的危险因素研究进展

社区获得性肺炎儿童发生气道黏液高分泌的危险因素研究进展

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气道黏液高分泌是儿童社区获得性肺炎的病理改变之一,影响肺炎严重程度、发展及预后.目前确定气道黏液高分泌依据支气管镜检查所见.为了评估发生气道黏液高分泌的风险,尽早干预,避免发生塑型性支气管炎以及缺氧、呼吸衰竭等严重后果,该文总结了年龄、临床特征及实验室指标与社区获得性肺炎儿童气道黏液高分泌发生率的关系.其中年龄、病原学种类、热峰及热程、中性粒细胞比值、C反应蛋白、乳酸脱氢酶、D-二聚体、血清25-羟基维生素D以及部分白细胞介素家族成员、干扰素及其他获得性免疫指标对社区获得性肺炎儿童气道黏液高分泌的发生具有预警作用.
Progress on risk factors involved in airway mucus hypersecretion in children with community acquired pneumonia
Airway mucus hypersecretion is one of the pathological changes in children with community acquired pneumonia(CAP),and affects the severity,progression and prognosis of CAP.Diagnosis of airway mucus hypersecretion currently relies on fiberoptic bronchoscopy.To predict the risk of airway mucus hypersecretion and to take early action to avoid serious consequences such as plastic bronchitis and hypoxia and respiratory failure,the article summarizes the relationship between age,clinical characteristics and laboratory indices and the formation of airway mucus hypersecretion in children with CAP.Among them,age,pathogenic species,fever peak and fever range,neutrophil ratio,C-reactive protein,lactate dehydrogenase,D-dimer,serum 25(OH)D,and some interleukins,interferons,and acquired immune indicators have an early warning effect on the development of airway mucus hypersecretion in children with CAP.

Community acquired pneumoniaAirway mucus hypersecretionPlastic bronchitisRisk factors

晏春愉、邓昱

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重庆医科大学附属儿童医院呼吸科 国家儿童健康与疾病临床医学研究中心 儿童发育疾病研究教育部重点实验室 儿童感染与免疫罕见病重庆市重点实验室 400014

社区获得性肺炎 气道黏液高分泌 塑型性支气管炎 危险因素

国家重点研发计划重庆市自然科学基金重庆市人力资源和社会保障局留学人员回国创业创新支持计划重庆市教育委员会科学技术研究计划重庆市科卫联合医学科研项目Chongqing Science and Health Joint Medical Research Project

2022YFC2704900cstc2019jcyjmsxmX0858cx2019068KJQN202000431渝卫发[2020]65号-2020FYYX0862020FYYX086

2024

10.3760/cma.j.issn.1673-4408.2024.01.008

国际儿科学杂志
中华医学会,中国医科大学

国际儿科学杂志

CSTPCD
影响因子：1.057
ISSN：1673-4408
年,卷(期)：2024.51(1)
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