摘要
社区获得性肺炎(community acquired pneumonia,CAP)是导致儿童死亡的主要原因,随着分子诊断技术的不断提升,发现更多的CAP是由病毒感染所致.目前已知影响病毒性肺炎严重程度的因素很多,其中包括病毒亚型、病毒毒力、宿主因素、环境因素等.也有研究发现病毒载量与病毒性肺炎严重程度相关,不同的病毒载量水平对病毒性肺炎严重程度的影响各不相同,与病毒种类、亚型、病毒标本采集部位、年龄、性别、合并感染等相关性也各不相同.该文综述常见的呼吸道病毒感染所致肺炎的病毒载量与疾病严重程度之间的关系.
Abstract
Community acquired pneumonia(CAP)is the leading cause of death in children,and as molecular diagnostic techniques continue to improve,more CAP is found to be caused by viral infections.At present,many factors are known to affect the severity of viral pneumonia,including viral subtypes,viral virulence,host factors,environmental factors,etc.Some studies have found that viral load is related to the severity of viral pneumonia,and different viral load levels have different effects on the severity of viral pneumonia.The correlation with virus type,subtype,site of virus specimen collection,age,sex and co-infection may be also different.This article will review the relationship between viral load and disease severity in pneumonia caused by common respiratory viral infections.
基金项目
广东省基础与应用基础研究基金项目(2021A1515010116)
NETL
NSTL
万方数据