抽动障碍与过敏性疾病的共病机制研究进展
Progress on the mechanism of comorbidity of tic disorder and allergic diseases
谢积强 1刘秀梅1
作者信息
- 1. 福建医科大学妇儿临床医学院福建省儿童医院(上海儿童医学中心福建医院)发育行为科,福州 350012
- 折叠
摘要
抽动障碍(tic disorder,TD)是一种以快速、不自主、非节律性、单一或多部位肌肉运动或发声抽动为特点的复杂的慢性神经精神障碍.TD和过敏性疾病均与机体免疫失衡相关,症状涉及不同部位或器官,发病机制复杂,严重影响生活质量.临床研究发现TD和过敏性疾病之间明显相关,但二者的关联机制至今尚不明确,主要涉及神经-免疫交叉障碍方面.该文综述TD和过敏性疾病的相关机制研究进展,以期加强对于二者共病的认知,为TD的病因学研究及治疗提供新的思路和方向.
Abstract
Tic disorder(TD)is a complex chronic neuropsychiatric disorder characterized by rapid,involuntary,non-hythmic,single or multi-part muscle movement or vocal twitching.Both TD and allergic diseases are related to the body's immune imbalance.The symptoms involve different parts or organs,and the pathogenesis are complex,which seriously affect the quality of life.Clinical studies have found a clear correlation between TD and allergic diseases,but the relationship mechanism is still unclear,mainly involving neuro-immune cross-disorders.This paper reviews the research progress of the relevant mechanisms of TD and allergic diseases,in order to enhance the cognition of the two diseases,and provide new ideas and directions for the etiological research and treatment of TD.
关键词
抽动障碍/过敏性疾病/神经递质/细胞免疫/微生物群-肠-脑轴Key words
Tic disorder/Allergic diseases/Neurotransmitters/Cell immunity/Microbiome-intestinal-brain axis引用本文复制引用
基金项目
国家自然科学基金面上项目(81871076)
福建省自然科学基金面上项目(2021J01424)
出版年
2024
NETL
NSTL
万方数据