LINGO-1,a Nogo receptor-interacting protein-1 rich in leucine repeat sequences and immunoglobulin structural domains,which is specifically expressed in neurological diseases.In recent years,more and more evidences indicate that LINGO-1 plays an important role in glial scar formation,cell death and inflammatory reaction.LINGO-1 inhibits oligodendrocyte activation,and prevents axon and myelin formation and functional recovery,and is therefore considered to be a negative regulator of neuronal survival,neurite extension and axon myelination.The change of LINGO-1 level is related to the occurrence and development of many neurological diseases.This article reviews the physiological function of LINGO-1 and summarizes the latest research progress of LINGO-1 in multiple sclerosis,spinal cord injury,neonatal brain injury and epilepsy,so as to explore new strategies for the treatment of neurological diseases.
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