LINGO-1在神经系统疾病中的研究进展
Progress of LINGO-1 in neurological diseases
刘嘉怡 1朱华 2苏学文2
作者信息
- 1. 内蒙古科技大学包头医学院 014000
- 2. 内蒙古自治区人民医院儿科,呼和浩特 010010
- 折叠
摘要
LINGO-1是富含亮氨酸重复序列和免疫球蛋白结构域的Nogo受体作用蛋白-1,在神经系统疾病中特异性表达.近年来,越来越多证据表明LINGO-1在神经胶质瘢痕形成、细胞死亡及炎症反应中发挥重要作用.LINGO-1会抑制少突胶质细胞活化,阻止轴突和髓鞘的形成和功能恢复,因此被认为是神经元存活、神经突延伸及轴突髓鞘化的负调节剂.LINGO-1水平的变化与多种神经系统疾病的发生和发展存在一定联系.该文对LINGO-1的生理功能进行阐述,并对LINGO-1在多发性硬化症、脊髓损伤、新生儿脑损伤及癫痫等神经系统疾病中的最新研究进展进行综述,旨在探寻神经系统疾病治疗的新策略.
Abstract
LINGO-1,a Nogo receptor-interacting protein-1 rich in leucine repeat sequences and immunoglobulin structural domains,which is specifically expressed in neurological diseases.In recent years,more and more evidences indicate that LINGO-1 plays an important role in glial scar formation,cell death and inflammatory reaction.LINGO-1 inhibits oligodendrocyte activation,and prevents axon and myelin formation and functional recovery,and is therefore considered to be a negative regulator of neuronal survival,neurite extension and axon myelination.The change of LINGO-1 level is related to the occurrence and development of many neurological diseases.This article reviews the physiological function of LINGO-1 and summarizes the latest research progress of LINGO-1 in multiple sclerosis,spinal cord injury,neonatal brain injury and epilepsy,so as to explore new strategies for the treatment of neurological diseases.
关键词
神经系统疾病/LINGO-1/轴突再生/少突胶质细胞活化/炎症Key words
Neurological diseases/LINGO-1/Axon regeneration/Oligodendrocyte activation/Inflammation引用本文复制引用
基金项目
内蒙古自治区自然科学基金(2018MS08067)
出版年
2024
NETL
NSTL
万方数据