The early prediction of umbilical cord blood S100β protein and lactate combined with amplitude integrated electroencephalogram in small for gestational age preterm infants with brain injury
Objective To explore the early predictive value of umbilical cord blood S100β protein and lactate combined with amplitude integrated electroencephalogram(aEEG)in small for gestational age(SGA)preterm infants with brain injury.Methods One hundred and six cases of SGA preterm infants were enrolled in this study in Neonatology Department of Inner Mongolia People's Hospital from January 2019 to December 2021.Umbilical cord blood serum S100β protein and lactate at birth of All SGA preterm infants were tested,and aEEG was monitored at 6h and 72 h after birth,corrected gestational age of 32 weeks and 37 weeks.According to the diagnostic criteria of brain injury in preterm infants,SGA preterm infants were divided into brain injury group(45 cases)and non-brain injury group(61 cases),and compared the differences of S100βprotein,lactate and the designated time aEEG between the two groups.SGA preterm infants with brain injury were further divided into symmetrical group(28 cases)and non-symmetrical group(15 cases).The differences of umbilical cord blood S100β protein and lactate level between the two groups were compared,and the diagnostic value in different types of SGA preterm infants with brain injury was also compared.Results SGA preterm infants in the brain injury group had significantly higher levels of umbilical cord blood S100β protein[(0.826±0.218)μg/L vs(0.397±0.196)μg/L,t=8.316,P＜0.05]and lactate[(8.5±1.3)mmol/L vs(3.8±0.9)mmol/L,t=3.281,P＜0.05]than those in non-brain injury group.Symmetric SGA group had higher level of S100β protein than the asymmetric SGA group[(0.924±0.205)μg/L vs(0.438±0.196)μg/L,t=5.734,P＜0.05].But there was no statistically significant difference in lactate levels[(5.6±1.4)mmol/L vs(3.9±1.2)mmol/L,t=0.932,P＞0.05]between symmetric SGA group and asymmetric SGA group.The abnormal rates of aEEG in brain injury group and non-brain injury group were respectively 100％(45/45)vs 22.95％(14/61)at 6 h after birth,95.56％(43/45)vs 16.39％(10/61)at 72 h after birth,62.22％(28/45)vs 6.56％(4/61)at 32 weeks of corrected gestational age,22.22％(10/45)vs 3.28％(2/61)at 37 weeks of corrected gestational age.The abnormal rate of brain injury group was higher than the non-brain injury group in the same nodal time,and the differences were statistically significant(X2 value respectively 62.292,64.913,38.074,9.257,all P＜0.05).Conclusion There were significant value in umbilical cord blood S100β protein,lactate level and aEEG monitoring in the early diagnosis in preterm infants SGA with brain injury.The combination of the three might be more helpful for the early diagnosis and timely treatment of brain injury in SGA preterm infants.
Umbilical cord bloodPremature infantsSmall for gestational ageS100β proteinLactateAmplitude integrated electroencephalogram
陈俊龙、王小丽、杨晓玲、苏学文、贾富华、武书丽
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内蒙古自治区人民医院新生儿科,呼和浩特 010017
内蒙古自治区人民医院门诊部,呼和浩特 010017
内蒙古自治区人民医院儿科,呼和浩特 010017
脐血 早产儿 小于胎龄儿 S100β蛋白 乳酸 振幅整合脑电图
内蒙古自治区卫健委科技计划项目内蒙古自治区卫健委科技计划项目内蒙古医科大学联合项目Joint Project of Inner Mongolia Medical University
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