特纳综合征患儿心血管疾病研究进展
Advances in cardiovascular diseases in children with Turner syndrome
胡斐涵 1王依柔 1王秀敏1
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心内分泌遗传代谢科 200127
- 折叠
摘要
特纳综合征(Turner syndrome,TS)是一种由女性第二条性染色体全部或部分缺失导致的疾病,每10万例新生女婴中约有20～50例TS患儿.大约一半的TS患者存在先天性或获得性心血管疾病.其中,先天性心脏畸形在TS患者中的发病率约为25％～50％;主动脉扩张在成人TS患者中较为常见,是主动脉夹层的重要危险因素.另外,TS患者比一般女性更容易出现心律失常.在儿童和青少年TS患者中,高血压的患病率较高,应用24h动态血压监测有利于TS患者高血压的诊断.因此,积极的健康教育、正确的随访、及时的干预至关重要.
Abstract
Turner syndrome(TS),a condition among females with a karyotype containing one X chromosome and complete or partial absence of the second sex chromosome,affects 20～50 in 100 000 newborn girls.Congenital or acquired cardiovascular diseases are present in about half of patients with TS.The congenital defects occur in about 25％～50％of TS patients;aortic dilatation as an important risk factor for aortic dissection is common in adult patients with TS.Furthermore,arrhythmias are found more frequently in patients with TS.A higher prevalence of hypertension in children and adolescents with TS has also been reported,and the application of 24h ambulatory blood pressure monitoring may facilitates the diagnosis of hypertension among these children and adolescent.Thus,active health education,correct follow-up and timely intervention are crucially needed.
关键词
特纳综合征/主动脉瓣二瓣化畸形/主动脉扩张/主动脉夹层Key words
Turner syndrome/Bicuspid aortic valve/Aortic dilatation/Aortic dissection引用本文复制引用
出版年
2024
NETL
NSTL
万方数据