过敏性哮喘是以慢性炎症、气道高反应为特征的复杂的、多基因相关的疾病.真菌、尘螨是过敏性哮喘最主要的吸入过敏原,并常以多种过敏原混合形式存在.近年来,遗传学研究证明多个基因与过敏性哮喘发作相关.该文主要对与尘螨、真菌所致过敏性哮喘相关的基因如解整合素-金属蛋白酶33(a disintegrin and metalloproteinase 33,ADAM33)、白介素4(interleukin-4,IL-4)、糖蛋白 A为主的重复序列(glycoprotein A repetitions predominant,GARP)、Toll样受体3(toll like receptor 3,TLR3)、甘露糖结合凝集素 2(mannose-binding lectin 2,MBL2)、趋化因子(CC基序)配体 17[chemokine(C-C motif)ligand 17,CCL17]等进行综述.
Progress on gene polymorphism of allergic asthma
Allergic asthma is a complex,polygenic disease characterized by chronic inflammation and airway hyperresponsiveness.Fungus and dust mites are the most important inhaled allergens of allergic asthma,and often exist in the form of mixed allergens.In recent years,genetic studies have shown that several genes are associated with allergic asthma attacks.This article reviews the studies on the genes related to allergic asthma caused by dust mites and fungus,such as a disintegrin and metalloproteinase 33(ADAM33),interleukin-4(IL-4),glycoprotein A repetitions predominant(GARP),toll like receptor 3(TLR3),mannose-binding lectin 2(MBL2),chemokine(C-C motif)ligand 17(CCL17)and other genes.
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