近年来,随着极早产儿存活率的提高,支气管肺发育不良(bronchopulmonary dysplasia,BPD)的发病率呈上升趋势.BPD是早产儿常见且严重的肺部并发症之一.虽然早产和肺部发育不成熟是BPD发生发展的主要高危因素,但是其确切形成机制目前仍不明确.沉默信息调节因子2相关酶1(silent information regulator 2 homolog 1,SIRT1)是去乙酰化酶蛋白质家族成员之一,在与BPD密切相关的炎症反应、氧化应激、细胞凋亡、细胞自噬及上皮间充质转化等过程中具有重要作用.该文对近年来SIRT1在BPD作用机制中的相关研究进行综述,为BPD发病机制研究及潜在的治疗靶点提供参考.
Silent information regulator 2 homolog 1 and bronchopulmonary dysplasia
Following the improvement of survival rate of very premature infants,the incidence of bronchopulmonary dysplasia(BPD)has been showing a rising trend in recent years.BPD is the most common and severe pulmonary complication in premature infants.Although prematurity and immature pulmonary growth are the most important risk factors in the development of BPD,the precise pathogenesis of BPD remains to be verified.Silent information regulator 2 homolog 1(SIRT1)belongs to sirtuin family,which plays an important role in the progress of inflammation,oxidative stress,apoptosis,autophagy and epithelial-mesenchymal transition,which is closely associated with BPD.Current studies of SIRT1 in the mechanism of BPD are reviewed in this article,which may provide reference for pathogenesis of BPD and potential therapeutic target.
Bronchopulmonary dysplasiaSilent information regulator 2 homolog 1Premature infantPathogenesis
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