肠道微生物群参与长新冠综合征发病机制的研究进展
Progress on the mechanism of gut microbiota in long-COVID-19 syndrome
袁静 1严向明 1金露旻1
作者信息
- 1. 苏州大学附属儿童医院儿科 215025
- 折叠
摘要
长新冠综合征(long-COVID-19 syndrome,LCS)是由新型冠状病毒感染引起的多系统长期综合征,肠道微生物群紊乱可能是其病因之一.LCS患者的肠道微生物群不同于健康者,且菌群变化持续时间长,菌群分布差异大.影响LCS发生和发展的潜在机制与肠-肺轴(gut-lung axis,GLA)、肠-脑轴(gut-brain axis,GBA)、潜在致病菌、菌群代谢产物等有关.基于肠道微生物群的LCS防治方法主要包括益生菌、益生元、粪便微生物群移植(fecal microbiota transplantation,FMT)等.阐明肠道微生物群参与LCS的发病机制可能有助于早期诊断和寻找新的生物标志物.
Abstract
Long-COVID-19 syndrome(LCS)is a multisystem and chronic disease caused by SARS-CoV-2,which can be attributed to the disorder of gut microbiota.Compared to healthy individuals,patients with LCS have different microbial communities,which can last for some time.The distribution of gut microbiota is different.Potential mechanisms that affect LCS may be related to gut-lung axis,gut-brain axis,potential pathogenic bacterias,microbial metabolites,etc.Prevention and treatment about LCS based on gut microbiota mainly contain probiotics,prebiotics,fecal microbiota transplantation,etc.Clarifying the relationship and pathogenesis between gut microbiota and LCS may contribute to early diagnosis and the research for new biological targets.
关键词
长新冠综合征/肠道微生物群/发病机制/菌群失调Key words
Long-COVID-19 syndrome/Gut microbiota/Mechanism/Dysbacteriosis引用本文复制引用
基金项目
苏州市医院协会苏州市科技发展计划指导性项目(SZSYYXH-2023-YB5)
苏州市科技局苏州市科技发展计划(SKY2023002)
苏州市科技局苏州市儿童结构畸形重点实验室建设项目(SZS2022018)
出版年
2024
NETL
NSTL
万方数据