Progress of non-invasive examination in the early diagnosis of ulcerative colitis in children
Ulcerative colitis(UC)presents as a chronic,non-specific intestinal inflammatory disease with an obscure etiology and pathogenesis.Early clinical manifestations in pediatric patients lack specificity,necessitating reliance on endoscopic of invasive examination,which is poorly tolerated,particularly by infants and toddlers.This review summarizes advancements in non-invasive diagnostic examinations for pediatric UC,emphasizing their value in early detection.Non-invasive imaging modalities,including intestinal ultrasound,CT enterography,and magnetic resonance enterography,can improve children acceptance.Serum autoantibodies,fecal calprotectin,non-coding RNA and other biomarkers also have potential application value for early clinical diagnosis.In addition,recent studies in intestinal microbiota and metabolomics analysis also hold promise for applying to early diagnosis in pediatric UC.
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