摘要
溃疡性结肠炎(ulcerative colitis,UC)是一种病因和发病机制尚不明确的慢性非特异性肠道炎症疾病.儿童UC早期临床表现缺乏特异性,诊断多采用内镜下侵入性检查,婴幼儿耐受性差.该文综述了目前UC患儿的非侵入性检查方法的研究进展,重点关注非侵入性检查在早期诊断中的价值.采用无创的肠道超声、CT肠道造影和磁共振肠成像等影像学检查可提高患儿接受度.血清自身抗体、粪便钙卫蛋白、非编码RNA等生物标志物对临床早期诊断也有潜在的应用价值.此外,肠道微生物和代谢组学分析近期在UC诊断中取得了一定进展,也有望应用于UC患儿的早期诊断.
Abstract
Ulcerative colitis(UC)presents as a chronic,non-specific intestinal inflammatory disease with an obscure etiology and pathogenesis.Early clinical manifestations in pediatric patients lack specificity,necessitating reliance on endoscopic of invasive examination,which is poorly tolerated,particularly by infants and toddlers.This review summarizes advancements in non-invasive diagnostic examinations for pediatric UC,emphasizing their value in early detection.Non-invasive imaging modalities,including intestinal ultrasound,CT enterography,and magnetic resonance enterography,can improve children acceptance.Serum autoantibodies,fecal calprotectin,non-coding RNA and other biomarkers also have potential application value for early clinical diagnosis.In addition,recent studies in intestinal microbiota and metabolomics analysis also hold promise for applying to early diagnosis in pediatric UC.
基金项目
南京市卫生健康委南京市医学科技发展项目(YKK21153)
NETL
NSTL
万方数据