2型固有淋巴细胞参与儿童哮喘气道炎症的研究进展
Progress on group 2 innate lymphoid cells in airway inflammation of asthma in children
朱思宇 1董晓艳 1赵然1
作者信息
- 1. 上海交通大学医学院附属儿童医院 上海市儿童医院呼吸科 上海交通大学医学院儿童感染免疫与重症医学研究院 200062
- 折叠
摘要
2型固有淋巴细胞(group 2 innate lymphoid cells,ILC2s)是参与儿童支气管哮喘(简称哮喘)气道炎症的关键免疫细胞.既往研究已经证明ILC2s过度激活与哮喘发病机制密切相关,此外,近年来研究又发现了多种与ILC2s免疫调节密切相关的调控因子,但ILC2s在哮喘气道炎症中的具体调控机制尚未完全明确.该文将围绕ILC2s与儿童哮喘气道炎症发病机制以及治疗方面的研究进展作一综述,总结ILC2s与气道炎症关系的研究进展以助于加深对哮喘发病机制的认识,并为哮喘诊治提供新的思路.
Abstract
Group 2 innate lymphoid cells(ILC2s)are critical immune cells involved in airway inflammation in childhood bronchial asthma(hereinafter referred to as asthma).Previous studies have demonstrated that over-activation of ILC2s is closely related to the pathogenesis of asthma and have identified a number of regulatory factors related to the immunomodulation of ILC2s,but the specific regulatory mechanism of ILC2s in asthma airway inflammation has not been clarified.The article will summarize the research progress on the pathogenesis and treatment of ILC2s and airway inflammation in childhood asthma.The summary of research progress on the relationship between ILC2s and airway inflammation can deepen the understanding of the pathogenesis of asthma and provide new ideas for the diagnosis and treatment of asthma.
关键词
儿童/2型固有淋巴细胞/哮喘/气道炎症/免疫/调控因子Key words
Children/Group 2 innate lymphoid cells/Asthma/Airway inflammation/Immunity/Regulatory factor引用本文复制引用
基金项目
上海申康医院发展中心临床研究项目(SHDC22021305-B)
出版年
2024
NETL
NSTL
万方数据