Progress on inflammatory bowel disease associated with IL-10 signaling pathway deficiency
Interleukin-10(IL-10)is an important anti-inflammatory cytokine in human body,which is mainly secreted by macrophages,Th1 cells and Treg cells.It can inhibit pro-inflammatory mediators,promote anti-inflammatory mediators,inhibit antigen presentation,inhibit immune cell development and promote repair by binding to IL-10 receptors.In recent years,the incidence of IL-10 receptor mutation-related inflammatory bowel disease(IBD)gradually have increased.It shows a younger trend,and the clinical manifestations are not typical,the effect of traditional treatment is not good,which affect the diagnosis and treatment of the disease,as well as the prognosis.This article describes the IL-10 axis and its immune function in IBD,the epidemiology,clinical characteristics and treatment of inflammatory bowel disease related to IL-10 receptor mutation.
NETL
NSTL
万方数据
