孤独症谱系障碍与肠道菌群干预的研究进展
Advances in autism spectrum disorder and gut microbiota intervention
平贤洁 1李宁2
作者信息
- 1. 滨州医学院特殊教育与康复学院,烟台 264003
- 2. 山东大学附属儿童医院(济南市儿童医院)济南市儿童保健所 250000
- 折叠
摘要
孤独症谱系障碍(autism spectrum disorder,ASD)是一组以社会沟通和社会互动障碍以及重复刻板行为为主要症状的神经发育障碍性疾病,其病因尚不明确.目前,国内外研究均显示,肠道菌群失调在ASD中普遍存在,重塑肠道菌群成为ASD治疗的热点.相关的干预方法主要包括益生菌、益生元和菌群移植.然而,其对ASD的有益作用仍然有限且尚未明确,未来仍需要进行更多、更大规模的深入研究来探索最佳治疗方案.该文综述了 ASD患儿肠道菌群的变化以及肠道菌群干预的研究进展,旨在为ASD早期诊断和治疗干预提供新思路.
Abstract
Autism spectrum disorder(ASD)is a group of neurodevelopmental disorders characterized by social communication and interaction disorders,as well as repetitive stereotyped behaviors,with unclear etiology.At present,domestic and foreign studies have shown that gut microbiota imbalance is commonly present in ASD,and reshaping the gut microbiota has become a hot topic in the treatment of ASD.The relevant intervention methods mainly include probiotics,prebiotics,and microbiota transplantation.However,its beneficial effects on ASD are still limited and uncertain,and more large-scale and in-depth research is still needed in the future to explore the optimal treatment options.This article reviews the changes in gut microbiota in children with ASD and the research progress on gut microbiota intervention,aiming to provide new ideas for early diagnosis and treatment intervention of ASD.
关键词
孤独症谱系障碍/肠道菌群/干预/益生菌/菌群移植Key words
Autism spectrum disorder/Gut microbiota/Intervention/Probiotics/Microbiota transplantation引用本文复制引用
基金项目
中国疾病预防控制中心妇幼保健中心母婴营养与健康研究项目(2022FYH008)
出版年
2024
NETL
NSTL
万方数据