Advances in biomarkers for early diagnosis of neonatal sepsis
Neonatal sepsis remains a main cause of neonatal hospitalization and mortality.Prompt and accurate diagnosis can reduce the use of empirical antibiotics and the problem of drug resistance associated with antibiotic overuse,and improve the long-term prognosis of patients.Biomarkers including hematological markers(white blood cell count and so on)and inflammatory markers(C-reactive protein,procalcitonin)have been employed in diagnosing neonatal sepsis,but they are not diagnositic.The current gold standard for diagnosing neonatal sepsis,blood culture,has limited value for early diagnosis due to limitations such as the time required and the low positivity rate.Several non-culture techniques,including molecular methods and mass spectrometry,can overcome some of the limitations of culture methods.This article offers an overview of the current research on biomarkers for the early diagnosis of neonatal sepsis,as well as an examination of new methods and technologies that may be employed for diagnosis in the future.
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