Progress on the mechanism of platelet involvement in tumour metastasis
Tumour metastasis is the primary cause of mortality in patients with tumours.Platelets are fragments of anucleated cells shed from the cytoplasm of mature megakaryocytes of the bone marrow,and involved in coagulation and the maintenance of vascular wall integrity.Recent studies have demonstrated that platelets participate in the host immune response by secreting granules containing a range of immunomodulatory and antimicrobial molecules,which are critical for tumour metastasis.In tumours,contact between platelets and tumour cells promotes platelet activation and aggregation.Activated platelets release a large number of reactive biomolecules that assist tumour cells in immune escape,migration,stationary adhesion and extravasation.Meanwhile,platelets accelerate tumour cell metastasis by inducing tumour epithelial mesenchymal transition,neoangiogenesis,metastatic ecological niche formation and other mechanisms.This article presents a review of the current state of research on the role of platelets in tumour metastasis,and offers insights into potential therapeutic avenues to enhance the survival of tumour patients.
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