儿童支气管哮喘外周血生物标志物的研究进展
Progress on peripheral blood biomarkers in children with bronchial asthma
宋玉萍 1罗蓉1
作者信息
- 1. 重庆医科大学附属儿童医院呼吸科 儿童发育疾病研究教育部重点实验室 国家儿童健康与疾病临床医学研究中心 儿童发育重大疾病国家国际科技合作基地 儿科学重庆市重点实验室 400014
- 折叠
摘要
支气管哮喘是儿童常见的慢性呼吸道疾病之一,主要表现为气道高反应性和慢性气道炎症,该病在表型、临床表现、病程及治疗反应上均存在差异.因此,需要更精确、易获取的生物标志物来进行诊断和评估.外周血生物标志物只需采集血液样本,可进行重复抽取且易于定量,有望提高哮喘的诊治效率,成为临床诊疗的一种选择.该文就近年发现的外周血生物标志物在识别儿童哮喘表型、评估严重程度以及预测治疗效果等领域的研究进展进行综述,以期为哮喘患儿提供个体化医疗策略.
Abstract
Bronchial asthma is one of the common chronic respiratory diseases in children,mainly manifested as airway hyperresponsiveness and chronic airway inflammation.The disease varies in phenotype,clinical presentation,course and response to treatment.Therefore,more precise and accessible biomarkers are needed for diagnosis and evaluation.Clinical assay of peripheral blood biomarkers only requires blood samples to be collected,can be repeatedly extracted and easily quantified,and are expected to improve the efficiency of asthma diagnosis and treatment,becoming a choice for clinical diagnosis and treatment.This article reviews the research progress of peripheral blood biomarkers in identifying the phenotype of childhood asthma,evaluating the severity,and predicting the therapeutic effect in recent years,with the aim to provide personalized medical strategies for children with asthma.
关键词
儿童/支气管哮喘/外周血/生物标志物Key words
Children/Bronchial asthma/Peripheral blood/Biomarker引用本文复制引用
出版年
2024
NETL
NSTL
万方数据