临床上偶见既往健康的儿童在感染新型冠状病毒之后不久出现严重的高炎症反应状态,主要表现为消化道症状、皮肤黏膜损害和心血管系统受累,被称为儿童多系统炎症综合征(multisystem inflammatory syndrome in children,MIS-C).该病易与其他全身系统性的急性炎症反应疾病混淆.MIS-C的发病机制尚未明确,可能与新型冠状病毒感染后继发的免疫失调有关.目前其诊断标准还未确立,该文综述MIS-C病例特点及研究进展,以期提高儿科医师对MIS-C识别、诊断及治疗的临床技能.
Multisystem inflammatory syndrome in children related to severe acute respiratory syndrome coronavirus 2 infection
Occasionally,previously healthy children develop severe hyperinflammatory syndrome shortly after infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which is mainly manifested as digestive tract symptoms,skin mucosal damage and cardiovascular system involvement.This disease is known as multisystem inflammatory syndrome in children(MIS-C),which is confused with other diseases manifested as systemic acute inflammation.The pathogenesis of MIS-C is not clear yet,and it may be related to immune disorders secondary to the SARS-CoV-2 infection.At present,its diagnostic criteria are not established.This article reviews the characteristics of MIS-C and the research progress,in order to improve the pediatricians'skill in recognition,diagnosis and treatment of MIS-C.
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