Neonatal hypoglycemia,a common disorder of abnormal glucose metabolism,occurs especially in preterm newborns.Hypoglycemia that occurs frequently and persistently may result in severe consequences for premature infants,including death or permanent brain damage.In recent years,an increasing number of research findings have demonstrated that the following conditions have been linked to an increased risk of hypoglycemia in preterm infants:maternal sickness during pregnancy,pharmaceutical use during pregnancy,and various pathophysiological states of the preterm infant.This review summarizes the current pathophysiological mechanism,risk factors,diagnosis,prevention,and treatment of hypoglycemia in preterm newborns through analyzing the pertinent literature that has been published recently both domestically and internationally,with the aim of early detection,early diagnosis and early treatment,and reducing the incidence of hypoglycemia.