儿童吉兰-巴雷综合征谱系疾病与抗糖脂抗体相关性研究进展
Progress on correlation between Guillain-Barré syndrome spectrum diseases and anti-glycolipid antibodies in children
苗新璐 1张俊梅1
作者信息
- 1. 中国医科大学附属盛京医院小儿神经内科,沈阳 110004
- 折叠
摘要
吉兰-巴雷综合征(Guillain-Barré syndrome,GBS)是一类免疫介导的急性炎症性周围神经病,随着对其表型认识的深入,逐渐形成了包含经典GBS和变异型GBS的谱系疾病.国内外多项研究发现,包括抗神经节苷脂抗体和抗Sulfatide抗体在内的抗周围神经膜表面糖脂抗体与GBS谱系疾病密切相关.抗糖脂抗体作为周围神经抗体的一部分,在GBS谱系疾病的诊断、临床分型、病情评估以及预后评估中发挥着越来越大的作用.该文对儿童GBS谱系疾病与抗糖脂抗体相关性的研究进展进行综述,以期为临床提供参考.
Abstract
Guillain-Barré syndrome(GBS)is a class of immune-mediated acute inflammatory peripheral neuropathy.With the in-depth understanding of its phenotype,a spectrum disease including classic GBS and variant GBS has been gradually formed.A number of studies at home and abroad have found that anti-peripheral nerve membrane surface glucolipid antibodies,including anti-ganglioside antibodies and anti-Sulfatide antibodies,are closely related to GBS spectrum diseases.As a part of peripheral nerve antibodies,anti-glycolipid antibodies play an important role in the diagnosis,clinical classification,disease assessment and prognostic assessment of GBS spectrum diseases.The article reviews the progress on the correlation between anti-glycolipid antibody and GBS spectrum disease in children,in order to provide clinical reference.
关键词
儿童/吉兰-巴雷综合征谱系疾病/抗糖脂抗体/临床表现/预后Key words
Children/Guillain-Barré syndrome spectrum disorder/Anti-glycolipid antibodies/Clinical manifestations/Prognosis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据