SOX家族基因在男性性别决定及男性生殖功能中的作用研究进展
Advances in the role of SOX family genes in male sex determination and male reproductive function
唐怡珺 1王秀敏1
作者信息
- 1. 上海交通大学医学院附属上海儿童医学中心内分泌代谢科 200127
- 折叠
摘要
SOX家族基因由于与SRY基因结构域相似而得名.在SOX家族基因中,SRY基因是哺乳动物性腺分化决定基因,直接决定了性腺向睾丸分化的方向;SOX9基因是性别分化过程中启动睾丸发育程序的重要基因;与SOX9结构域相似的SOX8、SOX2基因则在男性性发育与维持男性生殖功能中起到一定的作用.这些SOX家族基因的序列中都包含一段高度保守的结构域HMG序列.HMG的编码产物中都包含一组由79个氨基酸组成的蛋白质,起到结合和弯曲DNA的作用.因此,这些SOX家族基因的功能类似.该文综述了 SRY、SOX9、SOX8、SOX2等SOX家族基因在男性性别决定及男性生殖功能中的作用研究进展.
Abstract
Sex determination region of Y chromosome related HMG-box gene(SOX)was a group of related transcription factors with similar structures.In SOX family genes,SRY is the determinant gene of mammalian gonadal differentiation,which directly determines the direction of testis differentiation.SOX9 is an essential gene that initiates the development of testis during the process of sex differentiation.SOX8 and SOX2 also participate in sexual development and maintenance of male reproductive function.Similar to the SRY gene,these SOX family genes all have one high mobility group(HMG)domain.The product of HMG domain binds and bends specific target DNA.This article reviews the role of SOX family genes(SRY,SOX9,SOX8,SOX2)in male sex determination and male reproductive function.
关键词
SOX家族基因/性发育/性别决定/睾丸发育Key words
SOX gene/Sexual development/Sex determination/Testicular development引用本文复制引用
出版年
2024
NETL
NSTL
万方数据