Progress on the mechanism and treatment of steroid-resistant nephrotic syndrome in children induced by TRPC6 gene variation
Transient receptor potential cation channel 6(TRPC6)gene is mainly expressed in renal podiocytes.Its variation can lead to steroid-resistant nephrotic syndrome(SRNS),and the specific pathogenesis is not clear.These children have poor response to hormones and immunosuppressants,with lack of specific therapeutic drugs,and poor prognosis.In recent years,it has been found that some drugs can slow down disease progression by inhibiting the expression of TRPC6 gene or its downstream signaling pathway,and the discovery of TRPC6 protein-specific blockers may be the hope of treating such children.This review focuses on the pathogenesis of SRNS induced by TRPC6 gene variation in children and the research progress of drug therapy.
ChildrenGeneofTRPC6Variation of geneNephrotic syndrome
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