高迁移率族蛋白1(high mobility group box 1 protein,HMGB1)基因位于13q12染色体上,在各种组织细胞中普遍表达,编码的非组蛋白染色体结合蛋白调节转录,并参与DNA的修复,在炎症、细胞分化和肿瘤细胞迁移等过程中发挥重要作用,已成为多种疾病有价值的生物标志物.近年来,越来越多的研究发现该基因与儿童多种疾病密切相关,如呼吸系统疾病、消化系统疾病、自身免疫性疾病、心血管疾病等,该文就HMGB1基因与儿童疾病的研究进展进行综述.
Advances in HMGB1 gene and childhood disease
High mobility group box 1 protein(HMGB1)gene is located on chromosome 13q12 and is widely expressed in various tissues and cells.The encoded non-histone chromosome binding protein regulates transcription and participates in DNA repair.It plays an important role in processes such as inflammation,cell differentiation and tumor cell migration,and has become a valuable biomarker in a variety of diseases.In recent years,more and more studies have found that this gene is closely related to various diseases in children,such as respiratory diseases,digestive diseases,autoimmune diseases,cardiovascular diseases and so on.This article reviews the research progress of HMGB1 gene in children's diseases.
ChildrenHigh mobility group box 1 proteinHMGB1 gene
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