呼吸道病毒感染对哮喘的影响研究进展
Progress on the effects of respiratory viral infections on asthma
朱康 1金颖康1
作者信息
- 1. 广州医科大学附属妇女儿童医疗中心呼吸科 510623
- 折叠
摘要
呼吸道病毒感染是诱发支气管哮喘发生发展的主要风险因素.但哮喘患者气道内的抗病毒免疫反应却呈现受损过程,可导致病毒感染加重和急性哮喘发作.恢复机体的抗病毒免疫反应对于改善哮喘控制至关重要.该文阐述了呼吸道病毒感染对支气管哮喘发生发展的关键作用、哮喘患者的抗病毒免疫受损的机制,以及未来恢复哮喘患者抗病毒免疫反应的前景及潜在方法,以期为提高哮喘控制水平及寻求新的治疗靶点提供理论依据.
Abstract
Respiratory viral infections are the main risk factors for the occurrence and development of bronchial asthma.However,the antiviral immune response in the airways of asthmatic patients is impaired,which could lead to aggravated viral infections and acute asthma exacerbations.Restoring the antiviral immune response is crucial for improving asthma control.This article describes the key contributions of viral infections to the development of bronchial asthma,the mechanisms of antiviral immune impairment in asthmatic patients,and the future prospects and potential approaches for restoring antiviral immunity response,to provide theoretical justification for the improvement of asthma control and the search for new therapeutic targets.
关键词
支气管哮喘/抗病毒免疫反应/病毒感染Key words
Bronchial asthma/Antiviral immune response/Virus infections引用本文复制引用
基金项目
广州市科技局广州市科技计划项目(2023A04J1208)
广州医科大学附属妇女儿童医疗中心临床博士启动科研基金资助(2020BS002)
出版年
2024
NETL
NSTL
万方数据