Progress on PTPN11 mutation in the pathogenesis of juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia(JMML)is a clonal hematologic malignancy in childhood.The majority of JMML patients have gene mutations in the RAS/MAPK signaling pathway,with PTPN11(encoding Shp2 protein)being the most common gene mutation,accounting for 35％.In recent years,new research progress has been made on the pathogenesis of PTPN11 mutations in JMML,mainly involving new mechanisms such as other pathways,inflammatory response,hematopoietic stem cell overactivation,and the involvement of noncoding RNA in the occurrence of PTPN11 mutations in JMML.This article reviews the research progress of PTPN11 mutation in the pathogenesis of JMML.
PTPN11 mutationJuvenile myelomonocytic leukemiaPathogenesisRAS/MAPK signal pathway
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