Progress of vitamin D and its receptor gene polymorphisms and kidney diseases
Vitamin D works in the active form 1,25(OH)2D3 after binding to vitamin D receptor.Vitamin D deficiency is common in children with renal disease,and the abnormalities of vitamin D and its metabolic pathways are closely related to the occurrence and development of proteinuria and the deterioration of renal function.Vitamin D not only plays its classic role in maintaining calcium and phosphorus homeostasis,but also protects the kidney by improving the immune function of children,blocking the renin-angiotensin-aldosterone system,preventing the occurrence and development of proteinuria,alleviating the damage of podocytes,and delaying renal interstitial fibrosis.Therefore,this article reviews the research progress of vitamin D and its receptor gene polymorphism and kidney disease,in order to serve the clinical practice.
ChildrenVitamin DKidney diseaseVitamin D receptorGenetic polymorphisms
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