维生素D及其受体基因多态性与肾脏疾病的研究进展
Progress of vitamin D and its receptor gene polymorphisms and kidney diseases
王斌 1赵丽君 2苏昭源1
作者信息
- 1. 山西医科大学儿科医学系,太原 030001
- 2. 山西省儿童医院肾内科,太原 030000
- 折叠
摘要
人体内维生素D以活性形式1,25(OH)2D3与维生素D受体结合后发挥作用.维生素D缺乏在肾脏疾病患儿中普遍存在,且维生素D及其代谢通路中多个环节的异常与蛋白尿的发生发展及肾功能的恶化关系密切.维生素D除发挥维持钙磷稳态的经典作用外,还可通过改善患儿免疫功能、阻断肾素-血管紧张素-醛固酮系统、阻止蛋白尿发生发展、减轻足细胞损害、延缓肾间质纤维化等方式保护肾脏.该文通过对维生素D及其受体基因多态性与肾脏疾病的研究进展进行综述,以期为临床提供参考.
Abstract
Vitamin D works in the active form 1,25(OH)2D3 after binding to vitamin D receptor.Vitamin D deficiency is common in children with renal disease,and the abnormalities of vitamin D and its metabolic pathways are closely related to the occurrence and development of proteinuria and the deterioration of renal function.Vitamin D not only plays its classic role in maintaining calcium and phosphorus homeostasis,but also protects the kidney by improving the immune function of children,blocking the renin-angiotensin-aldosterone system,preventing the occurrence and development of proteinuria,alleviating the damage of podocytes,and delaying renal interstitial fibrosis.Therefore,this article reviews the research progress of vitamin D and its receptor gene polymorphism and kidney disease,in order to serve the clinical practice.
关键词
儿童/维生素D/肾脏疾病/维生素D受体/基因多态性Key words
Children/Vitamin D/Kidney disease/Vitamin D receptor/Genetic polymorphisms引用本文复制引用
基金项目
山西省中医药管理局科研课题(2023ZYYC048)
山西省儿童医院课题(2022029)
出版年
2024
NETL
NSTL
万方数据