ABCC4蛋白与相关疾病的研究进展
Advance in ABCC4 and related diseases
李维 1梁妍琰 2朱华3
作者信息
- 1. 内蒙古医科大学,呼和浩特 010020
- 2. 内蒙古自治区人民医院儿科,呼和浩特 010017
- 3. 内蒙古医科大学,呼和浩特 010020;内蒙古自治区人民医院儿科,呼和浩特 010017
- 折叠
摘要
ABCC4蛋白是ATP结合盒转运蛋白C亚家族中的一员,与细胞外信号通路和细胞保护有关.ABCC4作为一种多功能转运蛋白,广泛存在于人体的多种细胞中,能将多种内源性和外源性物质泵出细胞.ABCC4与多种疾病的发生发展有密切关系,也是多种疾病潜在的治疗靶点.该文就ABCC4的结构、功能及其在多种系统疾病中的相关研究进展进行综述.
Abstract
ATP-binding cassette subfamily C member 4(ABCC4),a member of ATP-binding cassette transporter C subfamily,is involved in extracellular signaling pathways and cellular protection.As a multifunctional transporter protein,ABCC4 is prevalently present in multiple cells of the human body,and is capable of pumping out a variety of endogenous and exogenous substances from cells.It is closely related to the occurrence and development of multifarious diseases,and is also a potential therapeutic target for many diseases.The structure,function and related research progress of ABCC4 in a large amount of systemic diseases are reviewed.
关键词
ABCC4蛋白/支气管哮喘/急性肺损伤/川崎病/机制Key words
ABCC4/Bronchial asthma/Acute lung injury/Kawasaki disease/Mechanism引用本文复制引用
基金项目
内蒙古自治区组织部"草原英才"工程(201640号)
出版年
2024
NETL
NSTL
万方数据