Advances in animal models of coronary artery lesion in Kawasaki disease
Kawasaki disease(KD)is a non-specific inflammation of small and medium-sized arteries in children.Some of these cases are accompanied by coronary artery damage,which has become one of the main causes of acquired heart disease in children in recent years.However,up to now,the molecular mechanism of mediating pathological changes of KD has not been fully understood at home and abroad.Therefore,the establishment of an animal model which is highly similar to the clinical pathological changes to make up for the scarcity of clinical samples is of great significance for the future study of the pathogenesis of KD.At present,KD mouse models inducers include Lactobacillus casei cell wall extract,Candida albicans water-soluble polysaccharide fragments,Candida albicans derivatives,and so on.This paper introduces the KD mouse models established by the above-mentioned inducers and the KD coronary artery damage models induced by serum or other causes in rabbits,young pigs and dogs.The related pathways and inflammatory factors involved may provide new ideas for early clinical diagnosis and targeted drug therapy of KD.
Kawasaki diseaseCoronary artery lesionInducerAnimal model
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