Advances in cytokines in Kawasaki disease with coronary artery lesions
Kawasaki disease,a common acute febrile and eruptive disease in children,can lead to coronary artery disease,emerging as one of the most common causes of acquired heart diseases.However,the pathogenesis of Kawasaki disease with coronary artery lesions is unknown,and interaction between inflammatory cytokines and Kawasaki disease with its coronary artery lesions remains to be elucidated.This paper reviews the role of cytokines in Kawasaki disease complicated with coronary artery lesions,and explores the specific mechanisms of inflammatory and anti-inflammatory factors in detail.Cytokines play a key role in the pathogenesis of Kawasaki disease and the formation of coronary complications.This review highlights that monitoring the levels of cytokines is of great value in predicting the risk of Kawasaki disease and coronary complications.In addition,it is expected that interventions,for example,inhibition of pro-inflammatory factors and enhancement of the activity of anti-inflammatory factors,could improve the prognosis of some children with Kawasaki disease,which has potential importance in clinical applications.
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