Advances in gut microbiota dysbiosis and hypertension in children
The incidence of hypertension in children has increased year by year in recent years.Hypertension in children can cause target organ damages(mainly kidney,cardiovascular system,or optic fundus),which may increase the risk of hypertension and cardiovascular events in adulthood.Therefore,the appropriate management is necessary and important.Life style changes and antihypertensive medication are the primary treatment options for children with hypertension.However,the blood pressure control rate is still at a low level.Studies have shown that gut microbiota and its metabolites play important roles in maintaining the homeostasis of the body and are closely related to cardiovascular diseases such as hypertension in children.Children with hypertension often have gut microbiota dysbiosis,fortunately,supplementation of probiotics and other microflora therapy had been found to reduce blood pressure levels in mice and human subjects.This article thoroughly examines the connection between gut microbiota dysbiosis and pediatric hypertension,considering primary hypertension,secondary hypertension,obesity,and other relevant factors,providing valuable insights for further research on the clinical significance of gut microbiota in treating pediatric hypertension.
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