Advances in augmented renal clearance in critically ill children
Augmented renal clearance(ARC)is a common phenomenon in critically ill pediatric patients,which can significantly impact the distribution and metabolism of renally excreted drugs.This,in turn,may lead to treatment failure,selective resistance,and adverse outcomes,garnering considerable attention in recent years.The etiology of ARC remains inconclusive but is generally thought to be associated with increased renal perfusion mediated by factors such as fluid resuscitation and vasoactive drugs.Although many domestic and international studies have focused on the prediction and pharmaceutical intervention of ARC,research on pediatric ARC still faces numerous challenges,including limited cases,inconsistent diagnostic criteria,and significant patient heterogeneity.PICU physicians should be aware of the importance of assessing ARC in critically ill children,actively monitoring and intervening to ensure early and adequate drug therapy,thereby benefiting the patients.
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