Advances in the diagnosis and treatment of early onset antinuclear antibody positive juvenile idiopathic arthritis
Early onset antinuclear antibody positive juvenile idiopathic arthritis is classified as a new separate type proposed by the International Experimental Organization for Pediatric Rheumatology in 2018,which differs from the classic classification method of the International Federation of Rheumatology Associations in 2001.Early onset antinuclear antibody positive juvenile idiopathic arthritis is defined by the onset before the age of 6 years,asymmetric arthritis,high incidence of chronic iridocyclitis,ANA positivity,and HLA-B27 related diseases,which are more common in girls.The clinical management of early onset antinuclear antibody positive juvenile idiopathic arthritis is challenging,and the awareness of this disease also needs to be improved.This article elaborates on the latest progress of early onset antinuclear antibody positive juvenile idiopathic arthritis in the aspects of epidemiology,etiology and pathogenesis,clinical manifestations and diagnostic criteria,differential diagnosis,treatment,outcome,and prognosis,in order to deepen the understanding of clinicians,improve the diagnosis and treatment level of this type of juvenile idiopathic artbritis,and make early diagnosis.
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