Progress on the role of nitric oxide and hydrogen sulfide in gastrointestinal motility disorder
Gastrointestinal motility disorder is a common disease in the gastroenterology department.Its incidence is increasing year by year,which seriously affects people's quality of life.Its pathogenesis is complex.Nitric oxide(NO)and hydrogen sulfide(H2S)are two types of gas signaling molecules.NO is an important neurotransmitter in the gastrointestinal nervous system,which is involved in the transmission of nerve signals and thus regulates smooth muscle.H2S plays an important role in regulating oxidative stress and maintaining cell balance,normal cell activity and body survival.At present,studies on NO and H2S are gradually emerging.This paper focuses on the relationship between NO and H2S and four primary dynamic diseases of digestive tract,such as achalasia of cardia,gastroesophageal reflux disease,gastroparesis syndrome,and false intestinal obstruction.
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