牛奶蛋白过敏(cow's milk protein allergy,CMPA)是由免疫球蛋白E(immunoglobulin E,IgE)、非IgE或二者混合介导产生的复杂免疫反应.新生儿作为一个特殊群体,其营养全部来源于母乳和(或)配方乳,易发生CMPA.研究表明遗传因素、环境因素、免疫因素、肠黏膜屏障、宫内致敏、饮食因素、分娩方式、孕周胎龄可能与新生儿CMPA的发生均存在一定关系.该文将综合以上方面,对新生儿CMPA的发病因素进行综述,为早期识别与干预提供临床依据.
Progress on the pathogenic factors of cow's milk protein allergy in neonates
Cow's milk protein allergy(CMPA)is a complex immune reaction mediated by immunoglobulin E(IgE),non-IgE or a mixture of the two.Neonate,as a special group,whose nutrition comes from breast milk and/or formula milk,are prone to CMPA.Studies have shown that genetic factors,environmental factors,immune factors,intestinal mucosal barrier,intrauterine sensitization,diet factors,delivery mode,gestational age may have a certain relationship with the occurrence of neonatal CMPA.This article will make a review on the pathogenic factors of neonatal CMPA from the above aspects,so as to provide clinical basis for its early identification and intervention.
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