Study of the relationship between level of placenta growth factor and pathogenesis of fetal growth restriction
Objective To explore the relationship between the level of placenta growth factor ( PLGF ) and the pathogenesis of fetal growth restriction ( FGR ). Methods Inmunoradioassay was used to measure the PLGF level of serum and cord blood in 17 pregnant women with FGR ( FGR group ) and 20 normal pregnant women ( control group ), and the results in both groups were analyzed. Results PLGF of the maternal serum in FGR group ( 38.12 ±0.91ng/L ) was significantly lower than that in the control group ( 40.41 ± 1.77ng/L ) ( t ＝6.74,P ＜ 0.05 ), and PLGF of the umbilical serum in FGR group ( 38.35 ± 1.10ng/L ) was also significantly lower than that in the control group ( 40.45 ± 1.46ng/L ) ( t＝ 2.35, P ＜ 0.05 ). The maternal serum PLGF was not correlated with that of the umbilical serum( r＝ 0. 120, P ＞ 0.05 ). It was not correlated with newborn birth weight ( r＝ 0.005, P ＞ 0.05 ). PLGF of umbilical serum was positively related with neonatal weight ( r ＝0.430, P ＜0.01 ). Conclusion The change of PLGF level may play an important role in the pathogenesis of FGR,and PLGF may provide a new direction for diagnosis and treatment of FGR.
国家科技期刊平台
NSTL
万方数据
维普
